Acne vulgaris (AV) is one of the most prevalent inflammatory skin diseases that affect young adults and even females over the age of 25. AV affects approximately 9% of the people worldwide, and adolescent prevalence ranges from 88% to 94%.

It may result in melancholy, nervousness, self-deprecation, psychiatric hospitalizations, school absenteeism, unemployment, and suicidality. Four factors contributed to the pathogenesis of AV: follicular colonization by Propionibacterium acnes (P. acnes), altered keratinization processes that lead to the development of comedones, inflammatory mediators around the pilosebaceous unit, and increased sebum production. The treatment approach depends on the severity of the AV, as the guidelines of countries around the world.

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