With the “omics” and bioinformatics analysis, PHYLOGENE offers a broad and hypothesis-free evaluation of the effects of cosmetics on the skin and / or its microbiota.

• Evaluation of the effects of cosmetics on cells, skin explants … by identification and relative quantification of the impacted proteins by mass spectrometry, followed by the complementary analysis of CORAVALID^TM data for a description of the positive and negative biological effects.

• QPCR (targeted) quantification of major genera / species of the skin microbiota to determine whether or not the product impacts the targeted entities.

• Evaluation of abiotic stresses (UV, blue light, pollution) complementing the above approach by RedOxMics^TM analysis of the sensitive amino acids redox modifications, and the OxDeep^TM oxidation index of the oxidation depth.

• Comparative metagenomic study of the microbiome of the skin by NGSequencing 16S rDNA and / or ITS to know the diversity and the taxonomic composition of the microbiome and to know if the product impacts or not the microbiome.

• Comparative metaproteomic study of the microbiota and the skin by nanoLC-MS/MS proteomics, and data complementary bioinformatic / biostatistical analysis by CORAVALID^TM and MicroXplore^TM for a functional description of the effects on the skin and its microbiota simultaneously in order to understand the mechanisms.

PHYLOGENE: http://ms.phylogene.com http://www.phylogene.com

Contact

62, Route Nationale 113

30620 BERNIS

Tel : +33 4 66 04 77 99
Fax : +33 4 66 04 77 97

e-mail :   gskorski@phylogene.com
web :      http://ms.phylogene.com

Click to access RedOxMics.Oxidation.ratios.220418.pdf

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