Zurko has a specialized division for safety evaluations with almost 20 years of experience.

Our team comprises of qualified technicians specializing in skin compatibility evaluation, supervised by an in-house dermatologist and collaborating medical professionals.

We conduct various studies under medical professional supervision, where quality and experience play an important role. The main safety evaluation studies conducted at Zurko are outlined below:

• Patch Epicutaneous Test

This study aims to verify the cutaneous compatibility of a cosmetic product after a single application under exaggerated experimental conditions. The product is applied once to the skin under a patch for 24, 48, or 72 hours. The compatibility is then evaluated visually by the responsible technical expert and the dermatologist in charge 30 minutes after the patch has been removed.

• Repeated or Single Open Application Test – Provocative Use Test

This study objective is to verify the cutaneous or ocular compatibility after repeated applications under experimental conditions.

The substances are applied by the technicians at the center once or twice per day during several consecutive days, usually 3 to 5 days. The compatibility is then evaluated under medical supervision (dermatologist, ophthalmologist, odontologist, etc.)

• HRIPT – Human Repeat Insult Patch-Test

The purpose of this study is to verify the cutaneous compatibility and assess the absence of any allergenic potential of a cosmetic product after repeated skin applications, under exaggerated experimental conditions.

The product is applied to the skin under patch 9 times during 3 consecutive weeks. After a minimum of two weeks rest period, the product is then reapplied under patch in duplicate sites.

The method used is an adaptation of the one described by Marzulli and Maibach.

• Photo Patch-Test

This objective of this study is to verify the cutaneous compatibility and the absence of phototoxic potential of a cosmetic product, after a single application on the skin under patch and UVA exposure.

For photo patch testing, two equal sets of testing product are prepared and applied on symmetrical areas of the back, avoiding the spinal for 24 hours. The volunteers are exposed to UVA radiation (10 J/cm2) on one test area and on an untreated control site. The readings are performed before the irradiation, and 24 and 48 hours after irradiation, by means of visual examination of the experimental area by the responsible technical expert as well as by the dermatologist in charge of the study.

• Home (Safety) In-Use Test

The purpose of this study is to evaluate the acceptability, subjective efficacy, safety/tolerance, and non-comedogenicity of a cosmetic product among the volunteers, monitoring possible adverse reactions during normal product use.

The study is carried out under the supervision of a medical professional(s) such as dermatologist, gynecologist, odontologist, pediatrician, ophthalmologist, etc.

Publi editorial

CONTACT

International Business Manager
jacob@zurkoresearch.com

Ph. +34 91 521 15 88

Avda. De la Osa Mayor,

4 28023 Madrid, Spain