Aging in the Dermis: Fibroblast Senescence and its Significance via Wiley

Informations Cam?ra: Calibration= 0,170 Microns par pixel; Format d'Acquisition= 2560 x 1920, Full Frame HQ; Gamma= 0,81; Gain= 1,0 x; Exposition= 16,8 ms; Exposition auto= Off; Type image= Couleur; Ombrage= x20; Accentuation= Off; R?duire noir= 3; R?duire blanc= 255; Infos microscope: Grand. Objectif Tourelle= 20; Changeur grand.= 1; Ouverture= 0.4;

Skin aging is characterized by changes in its structural, cellular, and molecular components in both the epidermis and dermis.

Dermal aging is distinguished by reduced dermal thickness, increased wrinkles, and a sagging appearance.

These events are regulated by signaling pathways, such as nuclear factor erythroid 2-related factor 2 (Nrf2), mechanistic target of rapamycin (mTOR), transforming growth factor beta (TGF-β), and insulin-like growth factor 1 (IGF-1).

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