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Aging in the Dermis: Fibroblast Senescence and its Significance via Wiley

Skin aging is characterized by changes in its structural, cellular, and molecular components in both the epidermis and dermis.

Dermal aging is distinguished by reduced dermal thickness, increased wrinkles, and a sagging appearance.

These events are regulated by signaling pathways, such as nuclear factor erythroid 2-related factor 2 (Nrf2), mechanistic target of rapamycin (mTOR), transforming growth factor beta (TGF-β), and insulin-like growth factor 1 (IGF-1).

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