The research has revealed more about the complexities of skin ageing and the importance of p53 mutations in regulating hyaluronic acid synthesis in keratinocytes. This, in turn, could aid the development of skin care/dermatology products and sunscreen formulations that protect against UV exposure in human keratinocytes and for melanoma cancer.

“The findings advance our understanding of cancer research, particularly melanoma cancer that originates in melanocytes attached to keratinocytes in the epidermis,” explained lead researcher Dr Kaustuv Basu, who worked with PI Dr Paraskevi Heldin and a team of researchers on the study.

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