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Study on percutaneous penetration of representative cosmetic ingredients in a baby wipe product in an in-vitro diaper rash skin model via Science Direct

Highlights

  • This in vitro diaper rash skin model based on the TEWL values measured in babies with mild and moderate to severe diaper rash.
  • A practical tool of estimating absorption of ingredients in baby products intended for diapered skin with diaper rash.
  • This diaper rash skin model helps understand an impact of diaper rash on absorption of bioavailability of ingredients via diapered baby skin.
  • The 100% dermal absorption is conservative for safety assessment on some ingredients via skin (intact and occasional diaper rash).
  • This diaper rash skin model may refine exposure to poorly and moderately absorbed ingredients for diapered baby skin.

 

Abstract

Studying percutaneous penetration of various cosmetic ingredients through intact and compromised skin can provide insight on quantitative exposure assessment for baby products intended for diapered skin. We developed an in vitro model (tape-stripped human skin) designed to achieve the Trans-Epidermal Water Loss values measured in babies with various degrees of diaper dermatitis.

Six reference compounds showed the impact of physicochemical properties on absorption through this “diaper rash” skin model. Under simulated diaper conditions, dermal absorption of cosmetic ingredients (phenoxyethanol, sodium benzoate, benzyl alcohol, disodium EDTA, and propylene glycol) was different, but <100%.

Additionally, the effect of diaper rash on dermal absorption of well-absorbed ingredients (phenoxyethanol, sodium benzoate, and benzyl alcohol) was limited (enhancement of 1.1–1.3), while the enhancement for moderately absorbed compounds (disodium EDTA and propylene glycol) was 1.8–3.3. Absorption via skin with “diaper rash” is specific to individual ingredients and exposure conditions, so a fixed uncertainty factor is not appropriate for safety assessment.

The data support that the default 100% dermal absorption commonly used in first-tier risk assessments for diapered skin is conservative. This diaper rash skin model provides a practical tool of estimating absorption of various ingredients in baby products intended for diapered skin.

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