The contribution of in-vitro models for the study of interactions between the sensory system and the skin by Neuron Experts via ZOOM#32

Skin is at the interface between body and environment and its role in preventing air dry or pathogen invasion is well known but it sensing role as to be highlighted. Indeed, skin is also the organ which allows individuals to react to their environment (temperature, pressure, cosmetics application, pollution…) and to inform brain about skin physiology (injuries, pathologies, pain…).

This complex sensing process is due to the presence of sensory neurons extension, axon, included in the different skin layers. Sensory neurons are not only passive sensors but reacts by releasing molecules such as neuropeptides into the skin that will activate the others skin cells.

Sensory neurons are thus active players in a large panel of biological phenomenon such as wound healing, inflammation, sensitive skin. Their role at the interface between the skin and the brain makes them an ideal target to improve both the physiology of the skin and the feeling of comfort of the person. As the crosstalk between sensory neurons and skin cells involve the release of molecules and the expression of key biological markers, it is possible, using in vitro methods, to measure these interactions.

Neuron Experts is thus developing models which, without using animal cells, make it possible to test the impact of ingredients or formulations on these neuron/skin interactions. By using the combination of different detection methods, we can not only determine the effectiveness of the products tested but also help determine their mechanisms of action and thus enhance their value. Drawing on our extensive experience in cell culture, we offer the development of personalized projects, to test compounds or creams on models such as reconstructed epidermis in coculture with neurons, so contact us to discuss your issues.