Background: Both aging, disease and malignant transformation of the skin are associated with changes in DNA methylation.

So far mostly invasive methodologies such as biopsies have been applied towards collecting DNA methylation signatures.

Tape-stripping offers a non-invasive option for skin diagnostics.

It enables the easy but robust capture biological material, in large numbers of participants without the need for specialized medical personnel.

Objectives: To design and validate a methodology for non-invasive skin sample collection using tape-stripping for subsequent DNA methylation analysis.

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