Publication Date: S
Neurons stochastically generated up to eight different versions of a protein-regulating neurotransmitter release, which could vary how they communicate with other cells.
In a new study of a key protein that regulates how neurons communicate via the release of neurotransmitters, scientists tracked how RNA editing affected the protein’s distribution and performance. Here three different edits of complexin (yellow) resulted in different distributions of the protein in segments of motor neurons as well as different degrees of function. The left panel shows distribution of unedited complexin while the right two panels show distribution of two different edited variants.
Credits: Image: Littleton Lab/Picower Institute
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