Hyperpigmentation refers to the darkening of skin color in specific areas, usually on the face, due to an overproduction of melanin, the pigment responsible for skin color. Facial pigmentation remains a clinical challenge for all dermatologists due to similar appearance despite the myriad of causes.
The most perplexing among them is the hyperpigmented disorder melasma. Melasma (also referred to as chloasma or the mask of pregnancy) is a common, acquired cutaneous pigmentary condition that results in mostly symmetrical, brownish pigmentation that affects the face and occasionally the forearms and back. With a prevalence of 1% and a potential increase to 50% in higher-risk groups that largely affects women, especially those with darker complexions and is primarily caused by ultraviolet (UV) exposure and hormonal factors.
Melasma is a cosmetic problem for patients with severity ranging from mild pigmentation to severe disfiguring hypermelanosis which may have a considerable impact on the quality of life. For the dermatologist, the biggest concern is its therapeutic difficulty. Therefore, it is essential to understand the etiology and pathogenesis of melasma.
The study of the pathophysiology of melasma has undergone a paradigm shift over time due to its diverse aetiologies. Melasma was earlier classified on the basis of the localization of melanosomes as epidermal, dermal, and mixed. Melasma is now thought to be due to a complex interaction between epidermal melanocytes, keratinocytes, dermal fibroblasts, and vascular endothelial cells, with hormonal and genetic factors, exposure to UVR and pollution contributing to the variability, dynamicity and the unyielding nature of this process.
An acute knowledge of the diagnostic dilemmas, cutting-edge diagnostic options, and the latest clinical research on the diagnosis and management of pigmentary disorders is paramount. At MSCR, they offer both in-vivo and in-vitro expertise in the field of research with the aid of their proprietary investigative and diagnostic equipment and experienced, proficient and accomplished in-house dermatologist specialist. They use state-of-the-art technology and the latest techniques to deliver the best possible results. Their testing process has been completely revolutionized through the collaboration of dermatological experts and the integration of advanced proprietary instrumentation and photo imaging technology. They have implemented the MSCR Software Analysis Programme to enable comprehensive imaging and analysis capabilities.
Additionally, the use of global images has transformed research completely by offering informative data and insights from diverse perspectives and locations, and MSCR is utilizing this tool in unique ways to maximize its potential. At their centre, they understand that every case of pigmentation is unique, which is why they use advanced diagnostic tools to precisely evaluate the condition and navigate hyperpigmentation studies. Their impressive facility and a vast volunteer database comprising 11,000 subjects from phototypes III – VI of both Indian and African origin, enables them to effectively conduct large-scale diverse and comprehensive population study of up to 300 subjects per study with meticulous planning and precise execution. Utilizing the latest techniques and their collective expertise, their team of experienced dermatologists work together to provide an optimal research environment and enhanced scientific claim support
MS Clinical Research is considered as the premier global research organization for carrying out studies connected to the treatment of hyperpigmentation, owing to their state-of-the-art infrastructure, cutting-edge tools and experienced team of dermatological pigmentation experts.
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