Advance your Solar Cosmetics Research : Customized State of the Art in vitro, & ex vivo Models by Monasterium Laboratory

28 July 2020

Monasterium Laboratory Skin & Hair Research Solutions GmbH is one of the most innovative CROs in the field of hair and skin research. Based on our strong roots in academic excellence, we have the world-class expertise in hair & skin research, pre-clinical and clinical services, and innovative methodologies for dermatological, therapeutic, and cosmeceutical applications.

We offer state of the art validated ex vivo models (human hair follicle organ culture & human skin organ culture) for testing the effect of compounds and, complex formulations used in solar cosmetics on hair and skin physiology. We employ advanced microdissection techniques to isolate hair follicles from human scalp skin or follicular units and culture them (amputated/full-length hair follicle or entire follicular unit) in a serum-free defined media. Our human hair follicle organ culture ex vivo models can be applied in various customized assays to answer specific questions related to sun care testing on human hair. Our well established in-house experimental readouts for hair follicle responses include hair cycle, pigmentation, cytotoxicity, aging, immunological phenotype, etc.

We also offer ex vivo cutting edge assays by applying culture of human skin samples in serum-free media. Our ex vivo models can be customized for application of test agents either added directly onto the epidermis at the liquid -air interphase (topical application), or to the medium (systemic application) or injected intradermally. The main advantages of our ex vivo human hair follicle & skin organ culture model are cost-effectiveness, animal-free, and clinically relevant test systems that can be efficiently used for pre-clinical evaluation of various active agents, SPF testing and we can test the full chemical formulations used in the development of solar cosmeceuticals.

In addition, our ex vivo models are very well suited to examine the effect of environmental factors such as ultraviolet radiation in skin and hair biology. We have recently developed an innovative ex vivo assay (published research) to investigate the impact on hair physiology when solar UV radiation hits the human scalp skin surface. Our advanced models can be applied to test agents/compounds or to identify novel sun photo-protectants for hair and skin against UV radiation.

Last but not the least, we also have the expertise in applying our in vitro models (human cell lines, human primary cells, 2D/3D culture models) to investigate early-stage compounds/agents used for developing solar cosmetics for efficiency, toxicity and dose-ranging studies.

Our vast worldwide network of scientific advisors, consultants, dermatologists from academia, and industry exemplifies our strong expertise and knowledge in the field of skin and hair research. We promise to provide our clients with the highest quality research – from the basic research question to industry-relevant translational research. Please do not hesitate to contact us if you have any queries, we are looking forward to supporting you to advance your solar cosmetic research.

Read the complete article: FOCUS#2 Solar Testing – Skinobs