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Amorepacific Discovers Skin Barrier Regulator EGR3 via Happy

Through skin barrier-related research aided by big data analysis, Amorepacific has identified the role and epigenetic mechanism of EGR3, a gene that regulates skin barrier formation.

The research results were presented under the title of “Skin Barrier Formation by Epigenetic Regulation of EGR3” at the Society for Investigative Dermatology’s annual academic conference, which took place online on May 3-8.This was the second time the company made a presentation at the academic conference. In 2019, Amorepacific became the first cosmetic company in Korea to make a presentation at an event held by the society.

The skin barrier is the primary layer that protects the body from various harmful factors in the external environment. Keratinocytes in the granular layer of the epidermis play an especially important role in the proper formation and functioning of the skin barrier. Despite an abundance of existing studies on how keratinocytes differentiate and develop, finding genes that comprehensively regulate those processes had not been an easy task, according to Amorepacific.

By Christine Esposito, Managing Editor – 05.13.21

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