Autophagy, a new way of substantiation for your products: autophagy and age!

ENVIRONMENT & AUTOPHAGY

The skin is daily subjected to various stresses, such as pollution, cigarette smoke, UVA, UVB… which alter cells.

These cell recycling/detoxification pathways represent markers for monitoring the impact of these stresses on cells.

Indeed, an aggression will stimulate these paths. A protective product may prevent the formation of damaged material within the cell and thus limit the activation of autophagy and mitophagy.

Specific markers are:
– 
LC3B, autophagy central protein,
– 
P62, main substrate,
– 
PINK1, mitophagy specific marker.

Additional markers such as MT1H, AhR, NRF2, HO-1, MDA… can also be studied in parallel to support your results.

AGE & AUTOPHAGY

Autophagy is one of the stress response mechanisms essential for the good maintenance of homeostasis. Activated in response to a lack of nutrients or identification of the damaged molecules, autophagy is involved in the processes of survival and cell longevity but it is also related to age.

It is known that, during aging, an accumulation of damaged cellular material to degrade occurs in parallel with an impairment of the cell degradation capabilities.

Our team correlated these data extracted from the literature with our explants model and observed a clear decrease in autophagy with age.

 

Barbara ROBIN

Chargée de communication scientifique et marketing

Tel : 01 69 41 47 63

@ : b.robin@bio-ec.fr

1 chemin de saulxier – 91160 Longjumeau

Tel : +33 (0)1 69 41 42 21 

 www.bio-ec.fr

Recent Posts

We Are Testing at HPCI India 2025

HPCI India has been an Industry-Connect Partner for 10+ years and has established itself as…

ADAT, experts in clinical data certification and analysis since 25 years

Welcome to ADAT Europe At ADAT, we are dedicated to providing state-of-the-art solutions in data…

We Are Testing at in-cosmetics Asia 2024 – The best place to talk about testing

in-cosmetics Asia is the leading personal care and cosmetic ingredient event in Asia Pacific, bringing…