Toxicology in Vitro will publish a study in December 2020 elucidating the partition and diffusion coefficients of some 50 compounds in intact skin and isolated skin layers and lipids.

According to the article, available online, the 7th Amendment to the Cosmetic Directive and REACH have mandated that in vitro methods be developed to assess the risk of chemicals for their potential toxicity. As such, Cosmetics Europe’s Absorption, Distribution, Metabolism and Elimination (ADME) Task Force is leading projects to help predict the local and systemic bioavail­ability of topically exposed compounds.

The present work, co-authored by researchers from The Procter & Gamble Company (Cincinnati), Procter and Gamble (Darmstadt), Pierre Fabre Dermo-Cosmétique, Beiersdorf AG and L’Oréal Research & Innovation, determined the partition and diffusion coefficients of 50 compounds in intact and isolated human skin layers. The compounds were selected for their relevance to cosmetics and included positive and negative reference chemicals.

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Published via Cosmetics & Toiletries, September 22th, 2020