The Centre for Cell Biology and Cutaneous Research brings together leading clinical and non-clinical scientists researching the cellular and molecular basis of epithelial diseases. Key strengths include, development of three-dimensional skin models, cancer biology and genetics, stem cells, epithelial signalling and gene discovery in genetic skin disease. The Centre maintains strong clinical links with Barts Health NHS Trust.
The Centre for Cell Biology and Cutaneous Research is a collaborative environment for working on keratinocyte and epithelial biology. Key strengths include development of skin three-dimensional models, cancer biology and genetics, extracellular matrix biology, epithelial signalling and gene discovery in genetic skin and related diseases.
Epithelial cell biology and stem cells
Current interests include development of engineered materials and model systems to study how cells within the skin sense and respond to mechanical and biophysical cues (Connelly), development of novel wound healing models and response to bacterial infection (Braun) and mechanisms of senescence and the interplay between cancer progression, healthy ageing and cell rejuvenation (Bishop). Other interests include epidermal steroid synthesis in healthy and diseased skin (Philpott), hair and keloid biology (Philpott) understanding normal skin basement membrane biology (O’Toole) and cellular signalling in epidermal differentiation (Bergamaschi and Kelsell). The Linton group are interested in membrane transporters and their roles in the pathophysiology of disease. The Greenwald group are interested in trans-cutaneous and non-contact diagnosis/assessment of vascular stiffness and endothelial function.
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