Our microbiota inhabit our body in symbiosis with our organs, intestine, skin, mouth, and even eyes and ears with specificities specific to each environment, and are in close relation with our organs.
And beyond the in situ action of microorganisms, the gut-brain axis or the gut-skin axis are now known as connections influencing the organs functioning and health.
Metaproteomics was used here as it allows a view on host and microbiota together based on molecules which are really involved in the biological processes.
Starting from a HiF diet mouse model of our partner Amylgen, we analyzed stools with metaproteomics and could then determine profound metabolism modifications as well as mechanisms related to resistance to obesity and diabetes, and suggest alterations on the“gut-brain axis” with, GABA modulating bacteria imbalance and related function modifications.
Metaproteomics coupled with bioinformatics is an efficient tool to reach the functional level of microbiota and host together.
With Phylogene, you can characterize and understand the microbiota metabolism and claim efficiently your products effects.
High-resolution nano LC-MS/MS quantitative proteomics and HolXplore™ data processing, Bacterial 16s rDNA and fungal ITS sequencing with OTU-based estimation to investigate microbial communities diversity and determine taxonomic composition: The efficient tools for discovery
Gilbert Skorski
PHYLOGENE
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30620 BERNIS
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Fax : +33 4 66 04 77 97
e-mail : gskorski@phylogene.com
web : www.phylogene.com
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Twitter : https://twitter.com/Phylogene_One
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