Optimal configuration of confocal Raman spectroscopy for precisely determining stratum corneum thickness: Evaluation of the effects of polyoxyethylene stearyl ethers on skin
Properties regarding stratum corneum (SC), the outermost membrane of the skin, remain an active area in dermatologic and cosmetic research. The reduced thickness of SC is associated with varied adverse statuses such as skin lipid deficiency, skin barrier dysfunctions and skin deceases, etc. Emulsifiers with existing irritative effects on skin components also face the risk of decreasing SC thickness.
We have been focusing on the effects of PEGylated emulsifiers on the skin and have an interest in finding the role of their polyethylene glycol (PEG)-chain length in tuning skin irritations. With this aim, PEG-stearyl ethers with different numbers of hydrophilic chains were applied on the skin, and their influence on skin thickness was discovered to determine their skin barrier effect. Confocal Raman spectroscopy (CRS) with extensive application in skin research was used here.
Published by ScienceDirect on March 15th, 2021
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