Glycation is a chemical process characterized by non-enzymatic reactions of glycosylation, a covalent binding of a sugar to a protein or lipid molecule, leading ultimately to the generation of complex mixtures of deleterious cross-linked compounds, named Advanced Glycation End-products (AGEs).
AGEs are increasingly accumulated over time, crosslinking to long-lived macromolecules such as elastin and collagen fibers and leading to maladaptive responses with structural and functional impairment of the cutaneous tissue. The consequences are visible signs of accelerated skin aging such as reduced elasticity and firmness, dehydration, weakened repair ability, appearance of wrinkles, and age spots.
To evaluate the anti-glycation potential of dermo-cosmetic compounds, StratiCELL provides a global approach combining both transcriptomic studies and specific bioassays.
The panel of in vitro assays include the quantification of cellular and tissue contents in AGEs, the measurement of cellular oxidative stress and inflammatory status as well as the analysis of the detoxification pathways such as autophagy and the proteasome activity. StratiCELL also studies AGEs receptor biology (expression, activity, signaling) and the effects of AGEs on the extra-cellular matrix modelling.
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