Identification of Novel Markers for Skin Senescence 6 Associated with the First Aging Peak of a Life Span by IFSCC

The mechanism of aging can be a very major target for the skincare strategy of cosmetics. Recent studies revealed that there are three major changes in age-related molecules over a life- time. Based on this study, we tried to select genes involved in nonlinear aging of the skin.

Among these age related molecules, we found that four genes, Fst/3, Gdf15, Mmp12, and Ccdc80, showed changes in the senescent skin cells. They showed similar gene expression patterns to those in senescent cells when irradiated with UVB.

and crocin. To evaluate whether the four genes correlate with skin aging, we performed an siRNA knockdown of Est/and Mmp12. We confirmed that the Fstl3 gene knockdown affects collagen and elastin production and the Mmp12 gene knockdown affects elastin production. In addition, it was confirmed that Bulbine frutescens ex tract can restore elastin production re duced by UVA by regulating Mmp12 gene expression.

On the basis of these results, it can be said that these four genes have the potential to act as skin aging markers. In this study, we discovered skin aging markers and elucidated their aging related functions. In addition, we discovered ingredients that regulate the expression of aging markers and are valuable as cosmetic skin anti-aging ingredients.