Dermatologists and cosmetic scientists are always interested in standardized biological models for better understanding the skin modifications at the tissue, cellular and molecular levels under different conditions (age, chemical, physical, microbiological stresses…).

Repetitive UV exposure of the skin is well known to elicit photo-aging mainly consisting of wrinkling and sagging the skin. [1]

AIM: Develop in vitro models of growing complexity and analysis of the relevance of these in vitro evaluation tools to better understand the cutaneous photo-aging process, particularly at the dermis level.

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