METHODS
We analyzed the relationship between the frequency of response at each sensation (stinging, burning, and itching) during a lactic acid sting test and the current perception threshold (CPT) value of each frequency.
To reconfirm this relationship, we analyzed differences of the CPT value (5 Hz) between the itch responder and non-itch responder groups.
RESULTS
here is a significant correlation between itch sensation and CPT values of 5 Hz. The itch responder group showed significantly lower sensory perception value of 5 Hz than the non-itch responder group.
CONCLUSION
The CPT value (5 Hz) can be used for scanning for itching sensations when a cosmetic or its ingredients possibly cause the sensation.
Neurometer CPT/C
Manufacturer: Neurotron, Inc. Baltimore Maryland USA
The Neurometer CPT/C testing system utilizes distinct frequencies of constant current stimuli to measure perception thresholds of 3 major subpopulations of cutaneous sensory nerve fibers. Its ability to measure small fiber function makes the patented Neurometer uniquely suitable for evaluating skin irritation, sensitization, and itch perception. “Sensitive” skin test subjects are identified easily by comparing their baseline scores to established normative data. A full range of specially designed electrodes allows for the testing of any cutaneous or mucosal surface.
The Neurometer® CPT® is a unique neurodiagnostic device that painlessly evalutes the functioning of small unmylenated (C), small myelinated (Aδ) and large myelinated (Aβ) sensory nerve fibers at any cutaneous site. It’s sensitive to both hypoesthetic and hyperesthetic abnormalities and more than 800 peer reviewed research publications document its diagnostic capabilities. Since receiving FDA clearance in 1986, more than a million CPT® tests have been conducted around the world
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