Best Of #9 Microbiome : Checking the Effects of an Ingredient with Genomic Tools by Phylogene

Evaluation of an active ingredient is requiring knowledge, dedicated tools to design and implement experimental studies. Elucidating the antimicrobial or soothing effects of a natural extract, understanding the direct and long lasting effects of a diet on gut and its microbiota are discipline 180 out apart… however we are doing it! With Phylogene, you can characterize impacts generated by ingredients, diets, diseases or drugs the microbiota as well.

Bacterial and fungal genus/species quantitative PCRs,
Bacterial 16s rDNA and fungal ITS sequencing with OTU-based estimation to investigate microbial communities diversity and determine taxonomic composition,
High-resolution nano LC-MS/MS quantitative proteomics and HolXplore™ data processing. The efficient tools for discovery Genomic

Genomic tools to evaluate effects of active molecules on skin microbiota’ repartition

Proteomic and metaproteomic tools to characterize direct and long lasting effects of a diet on gut microbiota

Proteomic tools to validate soothing effects of an active ingredient on rebuilt epidermis models.

1- Rhodomyrtus tomentosa Fruit Extract and Skin Microbiota: A Focus on C. acnes Phylotypes in Acne Subjects. Sandie Gervason et al, Cosmetics, July 2020
2- Laure Coutos-Thevenot, Jean-Marc Monneuse, Isabelle Metton, Francois Roman, Laura Ceolin, Vanessa Villard, Gilbert Skorski. Microbiome & Probiotics R&D & Business Collaboration Forum 2020
3- Cécile Bize, Elodie Gras Lavigne, Jean-Marc Monneuse, Aline Chrétien, Virginie Anchartechahar, Roland Hubaux, Gilbert Skorski, Michel Salmon, Remy Steinschneider. IFSCC 2020