Retinal cell death leads to loss of vision in complex, multigenic age-related eye diseases such as age-related macular degeneration (AMD), and monogenic eye diseases such as retinitis pigmentosa, Stargardt disease, Usher’s syndrome and Leber congenital amaurosis.
Disease Modelling
Inherited retinopathies affect 1 in 2,000-3,000 individuals. There are over 250 genes in the human genome associated with these diseases.
Newcells Biotech’s iPSC technology generates functional retinal organoids and their companion retinal pigment epithelium (RPE) to model the healthy human retina, that we can engineer to contain retinopathy-specific mutations and enable disease modelling.
Our iPSC-derived retinal organoids and RPE allow you to get better insights into retinal disease pathogenesis.
Drug Safety and Efficacy Testing
Drug-induced retinal toxicity is a relatively rare occurrence but with potential life-changing impact for patients.
Existing in vitro pre-clinical models for testing drug safety and efficacy are poor representations of the complex human retina.
Newcells Biotech’s iPSC-derived retinal organoids and companion RPE have a distinctive advantage over existing in vitro models; they are more accurate at in vitro to in vivo extrapolation (IVIVE).
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