Shiseido has established a unique technology that visualizes nerve fibers in the skin in three dimensions to a depth of about two millimeters including the deep dermis layer and revealed that peripheral nerve fibers decrease with age, and the components released from sensory neurons stimulate the production of collagen in fibroblasts, which are involved in skin elasticity.

Shiseido Findings to Develop Skin Care Products

The research team also found that the Labiatae plant-derived component Phytoconnect has the effect of activating sensory neurons and increasing collagen production. This study suggests the possibility of a new skin care regimen that can create firm skin by caring for the nerves and going forward, Shiseido will apply this finding to the development of skin care products.

3D Visualization of Nerve Fibers

Shiseido has been engaged in research to study the relationship between nerves and skin especially the epidermis. However, the conventional methods were limited in terms of observable area and accuracy, and it was not possible to fully understand the complex network structure of nerves deep inside the skin.

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