Most 3D models mimicking acneic skin do not take into account all of the four main components of this skin inflammation: hyper-seborrhea combined with a modification of the composition of sebum, colonization by Cutibacterium (C.) acnes, in particular the virulent phylotype IA1, hyperkeratinization and a secreted inflammation.
Multifactorial model
“Most 3D models mimicking acneic skin independently use hyperseborrhea or invasion by C. acnes to induce the characteristics of acneic skin,” said Silab. However, as these two factors are inter-related at the early stages of the pathology, the French manufacturer of cosmetic active ingredients sought to develop a 3D model combining sebum alteration and invasion by C. acnes.
Published by Vincent Gallon on February 12th, 2021