Brown skins-pots can appear after an overexposure to solar radiation, ageing or hormonal dysfunctions. Hydroquinone, mercurial derivatives, and corticosteroids are historical ingredients found in products intended to lighten the skin.

However, since different safety problems as irritation, allergy and due to its carcinogenic properties, hydroquinone and resorcinol are restricted according to Annex III of Cosmetic Regulation No. 1223/2009. Other skin-whitening agents are used such as kojic acid, azelaic acid, ascorbic acid, arbutin, …

Gas chromatography-mass spectrometry (GS/MS), high-performance liquid chromatography with UV/Vis detector (HPLC/UV-Vis) have been used to analyze these molecules. EXPERTOX proposes a method for separation and quantification of whitening agents to help cosmetic industries to control and ensure the safety assessment of their products.

Read the complete article: ZOOM16-Skinobs-pigmentation

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