A Compartmentalized 3D Model Combining Human reconstituted epidermis and sensory neurons derived from human iPSC
StratiCELL and Neuron Experts (Marseille, France) have developed a unique co-culture model combining human sensory neurons and reconstructed epidermis (RHE-HSN). This innovative model uses human sensory neurons derived from induced pluripotent stem cells (iPSC) that grow as a network in close proximity to a 3D reconstructed human epidermis, i.e. on the backside of the polycarbonate membrane (see below picture “RHE-HSN model”).
The model shows strong neuronal activity with pathways activation, including cell migration and regulation of epidermal regeneration. It allows to study the influence of ingredients or formulated products on processes involved in sensory skin and soothing properties, through the release of the neuropeptide CGRP upon capsaicin stimulation.
It is also possible to evaluate the morphology of the epidermis after treatment, to assess the secretion profile of the co-culture and to carry out gene or protein expression analyzes.
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