Recent publications remind us of the importance to understand and control skin cell senescence in order to delay the effects of aging.
Cellular senescence is caused by the exhaustion of the cell proliferative potential. Stress-induced premature senescence (SIPS) occurs after many different sublethal stresses including H2O2, UVB radiation, or hyperoxia. Cells in SIPS share common features with cells in replicative senescence: morphology, senescence-associated secretory phenotype, beta- galactosidase activity, cell cycle regulation, gene expression and telomere shortening.
Evaluates the efficacy of anti-aging and senolytic compounds to protect against stress induced senescence of human dermal fibroblasts or other cell types through a β-Galactosidase staining assay, soluble factors quantification, and through senescence related gene expression analysis (Toussaint, Salmon. Biochem Pharmacol. 2002, 64:1007). Contact us for further details
Read more: StratiCELLnewsletterOctober2018
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