StratiCELL’s in vitro Models for Inflammation and Atopic Skin

Loss of skin barrier function is generally associated with an increased inflammatory status which can lead to major skin disorders as seen in atopic skin. In order to restore this barrier and reduce inflammation, different classes of cosmetic ingredients exist, acting through various cellular mechanisms. The existence of in vitro models mimicking the in vivo situation, has greatly facilitated and still greatly facilitates the entry into the market of these beneficial active ingredients!

As a leader on in vitro efficacy testing, StratiCELL offers several skin models and efficacy tests associated with inflammation. In order to enlarge the field of investigation, the offer extends to :

• several different inflammatory models, either in the context of external aggression or chronic dysfunction such as atopic dermatitis or psoriasis;

• two complementary approaches for testing: a transcriptomic approach by studying the expression of target genes and a functional approach that highlights the beneficial actions of the active on the skin;
• a wide range of biological markers to cover all skin functions impacted by inflammation, from the skin barrier to the immune response;

• a comparison of the effects of an active to various positive reference molecules with known positive impact on cell signaling pathways restoring inflammatory disorders.

And StratiCELL goes beyond! The company continues to expand its range of services by associating its inflammatory models with components of the microbiological flora on one hand, and on the other hand with human neurons to cover the sensations of pain and itching.

Read more on anti-inflammatory and atopic skin testing by visiting www.StratiCELL.com/inflammation

And contact directly the experts on info@StratiCELL.com

info@StratiCELL.com

www.StratiCELL.com