New cosmetics and dermatological products rely more and more on in vitro screening platforms for early and ongoing efficacy assessment during product development. T-Skin™ is a new reconstructed skin full-thickness model that exhibits a well stratified, differentiated and self-renewing epidermis with a dermal compartment composed of functional fibroblasts embedded in a matrix of collagen I.

• This poster presents characterization by immunohistochemistry of intracellular and extracellular biomarkers located in epidermal, dermal-epidermal junction and dermal compartment of T-Skin™ compared to normal human skin.

• Application in the field of anti-aging studies is investigated by the functional response of T-Skin TM after applying reference anti-aging actives, Vitamin C (L-ascorbic acid) and Retinol.

• When exposed to UVs, key players of skin photo-aging, the induced biological changes in T-Skin™ are observed at epidermal and dermal levels by immunohistochemistry, histology and inflammatory cytokines production.

Upload the poster: 2018-IID-TSKIN-posterV2-1

http://www.episkin.com/News/The-EPISKIN-Academy-at-the-IID-2018