The biology of smell is a mystery – AI is helping to solve it via Nature

The smell in the laboratory was new. It was, in the language of the business, tenacious: for more than a week, the odour clung to the paper on which it had been blotted.

To researcher Alex Wiltschko, it was the smell of summertime in Texas: watermelon, but more precisely, the boundary where the red flesh transitions into white rind.

“It was a molecule that nobody had ever seen before,” says Wiltschko, who runs a company called Osmo, based in Cambridge, Massachusetts. His team created the compound, called 533, as part of its mission to understand and digitize smell. His goal — to develop a system that can detect, predict or create odours — is a tall order, as molecule 533 shows.

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