Hydration is one of the main markers of skin well-being and depends on fine mechanisms for regulating the water content in the skin compartments.

The in vitro approaches for the experimental investigation are based on these mechanisms. Some of the aspects that can be taken into consideration are the enrichment of molecules with high affinity for water in the dermal matrix (hyaluronic acid and glycosaminoglycans in general), the integrity of the epidermis and the composition of NMF (Natural Moisturizing Factor) on the skin surface, the expression of channels for water and in particular aquaglycoporins for the regulation of exchanges and selective permeability to water, glycerol and urea. All these parameters, studied by means of biochemical, molecular biology and immunostaining techniques, contribute to investigate the “hydration mechanism” in the skin.

For further information on these in vitro methods, please contact COMPLIFE on info@complifegroup.com

or visit us on booth AA31 at In-Cosmetics Global in Barcelona

www.complifegroup.com