Understanding the Mechanisms of the Skin Inflammation in Acne by Phylogene

Skin is the largest organ to repel attacks from external agents and functioning as both a physical and immunological barrier, performing a wide range of innate and adaptive immune functions. Its glandular nature and bacteria rich composition is making it prone to inflammation and infections. In the recent years the human microbiota and its modulation of the inflammatory response have become the subject of intensive research. Although the microbiome and its multiple role in the gastrointestinal tract came into light, the role of the skin microbiota remain far less understood. Metagenomic analysis such as 16s ribosomal gene sequencing provided tremendous insights into taxa’ ecosystem on the skin while metaproteomic analysis could unravel functional interactions between microbiota and hosts, paving the way for understanding the mechanisms of action underlying skin inflammation in acne.

With PHYLOGENE, characterize and understand microbiota metabolism on skin.

High-resolution nano LC-MS/MS quantitative proteomics and HolXplore™ data processing: The efficient tool for discovery

Bacterial 16s rDNA and fungal ITS sequencing with OTU based estimation to investigate microbial communities diversity and determine taxonomic composition.

Read the entire ZOOM#19 : ZOOM#19-Blemishfree testing-SKINOBS.web