New eye and skin irritation test guidelines for make-up and personal care products by Cosmetics

31 August 2015

By Deanna Utroske, 26-Aug-2015

The Organization for Economic Co-operation and Development has published two novel eye irritation testing
protocols and updated several skin testing guidelines.
Both new in vitro eye assays are meant to help scientists establish which chemical ingredients do not need to be labeled for eye irritation or damage.

Test number 491
The first new testing guideline is for a short, five-minute exposure test and relies on cultured rabbit cornea cells. The
organization prescribes a quantitative assessment of both cytotoxicity and cell viability following quick chemical exposure….

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Test number 492
The OECD’s second new eye irritation experiment is called a reconstructed human cornea-like epithelium test method. This test “evaluates the ability of a test chemical to induce cytotoxicity in a RhCE tissue construct, as measured by the MTT assay,” according to the abstract. And notably, “colored chemicals can also be tested by use of an HPLC procedure.”…
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Rabbit skin substitutes
Four skin irritation tests already published by the OECD were updated earlier this summer. Those “alternatives to the rabbit test for skin irritation…

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