Skin is the largest organ to repel attacks from external agents and functioning as both a physical and immunological barrier. Its glandular nature, bacteria rich composition and rather rapid cell turnover is propitious for a wide range of innate and adaptive immune functions. Daily traumatized by naturally occurring abiotic stress (UV induced Oxidative stress, blue screen, cigarette smoke, pollutants) and physical traumas (inflammation, disruption of cell integrity), skin regeneration is paramount. In the recent years, the role of the human microbiome in the gastrointestinal tract and skin inflammatory responses modulation has been subject to intensive research.
Omics techniques are the spearhead of these research processes and metaproteomics and phosphoproteomics are of particular interest. “Decreased DNA damage, reduced inflammation, dynamic regulation of cell cell and cell-matrix interaction, increased cell motility, increased lipids metabolism, increased migration and wound healing” are claimable phenomenon reached by metaproteomics and phosphoproteomics analysis when associated with bioinformatics protocols. While Metaproteomic analysis could unravel functional interactions between microbiota and hosts, Phosphoproteomics could unravel cosmetics / dermocosmetics treatments benefits, at the cellular level.
With PHYLOGENE characterize and understand microbiota metabolism on skin, as well as post translational modifications (PTMs) to understand the effects of your product on mechanical integrity and skin properties. High-resolution nano LC-MS/MS quantitative proteomics and HolXplore™ data processing: The efficient tool for discovery
www.phylogene.com | Corporate and testing sheet: https://skinobs.com/preclinical/labo.php?id=222
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