Using our original technology that makes tissues, such as skin, transparent and visualizes their specific structures in three dimensions, we observed the positional relationship between the capillary network and epidermal stem cells.

Shiseido has become the world’s first to discover that pericytes, which adhere to the outer side of dermal capillaries, may promote epidermal regeneration by moving from the capillary loop to the epidermis and transforming into the cells akin to epidermal stem cells.

We also found that aging causes variance in the direction of capillary loop running toward the epidermis, resulting in the creation of distance between the capillaries and the epidermis.

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