Four decades of the Human Genome Project and its consequences have shown how the entrepreneurial state, through sig-nificant investment into science, can drive scientific progress and advance biomedicine.

A certain fraction of diseases can now be explained as caused by genetics, and a more significant fraction as impacted by genetics.

Besides another fraction caused by pathogens, the third and probably largest impactor is exposure, i.e., the many physicochemical and lifestyle factors.

This article makes the case that it is time to start a Human Exposome Project, which systematically explores and cat-alogs the exposure side of human health and disease.

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