Age-dependent Changes in Epidermal Architecture Explored Using an Automated Image Analysis Algorithm on In Vivo Reflectance Confocal Microscopy Images via Wiley Online Library

Reflectance confocal microscopy (RCM) is an in vivo imaging technology that enables the visualization of the epidermis and upper layers of the papillary dermis at the cellular level. It provides real-time optical sections of the epidermis at sequential depth, thus giving information about the 3D structure of the observed area. The energy of the incident light does not initiate any photobiological process in the skin, hence, allowing the observation of cells in situ without a change in their structure or function.

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