Analyse Inflammation with the C-Cube CR System by Pixience

12 June 2023

Sensitive skins naturally tend to be more inflamed than other skin types. This is the body’s way of defending itself against internal and external aggressions on the skin barrier.

Local irritation can be initiated by contact with everyday substances. Inflammation can take many forms, and can result in red, rough skin, rashes and blemishes.

This way, many anti-inflammatory agents are incorporated into skincare products to improve skin tone and texture. Clinical trials are necessary to ensure that dermo-cosmetic products do not cause an inflammatory reaction or to test the effectiveness of your anti-inflammatory creams and treatments.

More than a chromameter, C-Cube CR 3 is a specific device for skin’s color and surface analysis. It is specifically designed to be used in cosmetic clinical trials. French leader in digital dermoscopy, Pixience works closely with dermatologists and researchers to develop high quality products for skin and hair imaging and analysis.

An exclusive method of metric and color calibration makes the C-Cube CR 3 the only dermoscope to provide reproducible colors, correlated with a spectrophotometer. Thanks to its ease of use and flexibility, it integrates seamlessly and painlessly your clinical trials.

You improve your analysis sensibility by circling, or targeting, precise regions of interest directly on the very high-resolution photographs it produces.

With its CIE L*a*b* COLOUR measurements, the C-Cube CR 3 allows you to image and measure the degree of effectiveness of your active ingredients on the skin and scalp. Thanks to the data contained in each pixel and the placement of the ROIs in the image, you ensure control and precision in your studies.

You can also make 3D acquisitions of skin’s surface. Using a technique called photometric stereo, the C-Cube system analyses multiple images under different lighting conditions to estimate surface normals. 3D captures can be done in-vivo or using silicone replica in the Sample Reader. Combined with a geometric calibration the software produces elevation information at each pixel. 3D captures allow for exemple to viasualize and analyze microrelief in order to evaluate his isotropy.

Accurate and reliable color measurements allow the evaluation of many of the skin’s characteristics such as erythema, roughness, acne, and pigmentation evenness.

Erythema: Observe the presence of erythema. The software allows you to obtain colour-mapped image of the study area (red for areas affected by erythema, blue for areas not affected). You can compare this image with an erythema index to characterise and locate it precisely.

Pigmentation evenness: The C-Cube CR software provides the amount of melanin through an index called pigmentation index. It also provides the Individual Topology Angle (ITA) for the area. The C-Cube Clinical Research software also calculates the standard deviation for both pigmentation criteria.
Roughness: Skin roughness can be analysed with C-Cube CR 3. Combined with a geometric calibration the software produces elevation information at each pixel and the roughness parameters Sa, Sq and Sdr. Sa and Sq represent the average distance (respectively arithmetic and quadratic) to the average elevation of the ROI. Sdr, is expressed as the percentage of additional surface area contributed by the texture as compared to the planar definition area.

Acne: Pimple elevation is an important characteristic of the severity of the inflammation and may be reduced. The peak height (Sp) and total amplitude (Sz) of a ROI is processed and can be monitored to show product efficacy.

Conducting your clinical studies with the C-Cube CR 3 ensures that you can quantify all types of skin inflammation manifestations.

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