International regulatory bodies require skin care products to be safe for use and not harmful to human health when applied under normal and reasonably foreseeable conditions. To ensure product safety, manufacturers must obtain adequate information, which may require clinical studies and specific testing techniques such as the Human Repeat Insult Patch Test (HRIPT), non-comedogenicity test, and Tear-Free Test .

These tests can help them identify any potential issues with the product and make necessary changes before it gets introduced into the market. For example, HRIPT is designed to assess the potential irritation or allergic reactions that a product may cause on users.

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