Fragrances are important contact allergens; however, investigation of their skin sensitization potency has been challenging in new approach methods (NAMs). Many fragrance chemicals are susceptible to autoxidation or can be metabolized by enzymes constitutively expressed in skin keratinocytes. Strong sensitizers can be formed in both of these processes. Further, keratinocytes can modulate the dendritic cell (DC) activation and maturation potential, a key event in the acquisition of contact allergy.
tac
Welcome to this 33rd edition of ZOOM, a magazine dedicated to preclinical trials and clinical…
Precision and reliability are essential in dermatology and aesthetics. The Antera 3D CS by Miravex…
PhD Trials, one of the leading CROs for performing in vivo studies with cosmetic products…