Fragrances are important contact allergens; however, investigation of their skin sensitization potency has been challenging in new approach methods (NAMs). Many fragrance chemicals are susceptible to autoxidation or can be metabolized by enzymes constitutively expressed in skin keratinocytes. Strong sensitizers can be formed in both of these processes. Further, keratinocytes can modulate the dendritic cell (DC) activation and maturation potential, a key event in the acquisition of contact allergy.
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The skin is densely innervated by a complex network of nerve fibers responsible for detecting…
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Georgina Caldwell 28 February 2025 THE WHAT? Shiseido’s patented, proprietary optical clearing technique, which makes skin…