Skin is the largest organ to repel attacks from external agents and functioning as both a physical and immunological barrier. Its protective layer essentially composed of proteins and lipids such as keratins, filaggrins, involucrins are the essential components of the cornified envelope. Collagen and elastin found in deeper layers of the skin are among others principally engaged in skin mechanical properties. UV induced Oxidative stress, blue screen, cigarette smoke, pollutants; Naturally occurring abiotic stress so to speak, is a major factor affecting skin.
These effects can be investigated using proteomics and phosphoproteomics when associated with dedicated bioinformatics. A Complete investigation focused on proteins oxidation can now be done with RedOxMics™ and OxDeep™, with 18 redox modifications of 10 amino acids investigated and the deepness of the skin stress assessed.
With MS-Phylogene, you can assess the stress protection potential of your actives and understand the effects on skin mechanical integrity and property.
High-resolution nano LC-MS/MS quantitative proteomics and CORAVALID™ data processing: The efficient tool for discovery.
https://www.phylogene.com/| corporate and testing sheet https://skinobs.com/instrumentation.php?id=140
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Gilbert Skorski
CEO
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