iPSC-derived sebocytes to study their role in alopecia, by Phenocell

Alopecia and hair thining have been linked to excessive lipid contents on the scalp. The sebaceous gland contributes to sebum production, which physiologically helps to seal in moisture and prevent desiccation of the skin. Excessive sebum production in androgenic alopecia is linked to a marked increase in the size of the associated sebaceous gland, suggesting that overgrowth of the gland and effects of the follicular stem cells are important factors in hair loss. With their range of in vitro assays based on iPSC-derived sebocytes, they can investigate the efficacy of ingredients and molecules on sebum production, including after androgen-receptor stimulation.

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