After the first validations of the product toxicology, preservation (challenge test), stability comes the necessity to ensure the consumers safety. To evaluate the safety of cosmetics the first actor will be the toxicologist who will quantitatively and qualitatively review the product formula. In a second step, testing laboratories will process to the safety assessment via in silico analysis, on chemicals, cells or on skin models. Once the product innocuity is fully validated, tolerance studies can start on human beings. In this article we will present the several ways, the most used to evaluate the safety and the tolerance of cosmetics to make them safe for the consumers, wherever there are used in the world.

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