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Study shows efficacy and safety of DMN patch containing skin depigmentation agent via Cosmetics Design Europe

18 April 2016

By Andrew McDougall – 15-Apr-2016

The future of functional ingredient delivery in anti-ageing and cosmetics could be done using a dissolving microneedle (DMN) patch after a new study verified a prototype for its safety and efficacy.

A research team from Korea, made up of scientists from Yonsei University, Dermapro Skin Research Center, and Hoseo University, developed a patch containing 4-n-butylresorcinol for skin depigmentation and say it could become useful as a functional cosmetic product.

“The DMN patch was effective and safe for skin depigmentation through targeting of melanocytes,” says the study.
“The DMN patch has potential to be an advancement in the field of cosmetics because the patch could be fabricated using
various functional ingredients, such as depigmentation and anti-ageing agents, and because of their usability, safety, and


Efficacy and safety

For the efficacy assessment, the 4-n-butylresorcinol DMN patch was compared with a control (DMN without the functional agent) in a double-blind, placebo-controlled study with 45 subjects by measuring two parameters: the melanin index and individual typology angle value, during 8 weeks of administration.
The results showed that the 4-n-butylresorcinol DMN patch was safe based on the results of the safety assessment and
was more than two times more effective than the control patch. “The 4-n-butylresorcinol DMN patch was effective and safe for skin depigmentation through targeting melanocytes and could be a useful functional cosmetic product,” concludes the study, published in the Journal of Cosmetic Dermatology .


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