Historical perspective
The announcement of the discovery of mRNA and cracking of the genetic code occurred within weeks of one another in 1961.3 To identify mRNA and elucidate its role in protein synthesis was complex and is credited to as many as 9 researchers from a series of different groups over time.4 In the 1970s, scientists began researching how to deliver mRNA into cells for therapeutic purposes before it would be degraded. In the 1980s recombinant RNA polymerase was developed, which enabled the large scale…