The skin is continually exposed to environmental stressors, with air pollution constituting a major component of the skin exposome. Urban pollutants contribute to acne flares, excess sebum production, pigmentation disorders, and unpleasant sensations (itching or stinging). These effects arise from oxidative stress and inflammatory pathways that disrupt the proper functioning of sebocytes, melanocytes, and cutaneous sensory nerve endings, amplifying skin imbalance and discomfort.¹
Human iPSC-derived skin models offer a physiologically relevant way to study skin dysfunctions, enabling assessment of sebum production, pigmentation, cell viability, sensory response, and testing protective or corrective actives.
Axol Bioscience provides human iPSC-derived skin models for acne and hyperseborrhea, active compound testing and pigmentation assays. Contact us: operations@axolbio.com.
Reference
Krutmann J. et al. The skin aging exposome. J Invest Dermatol. 2017.
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