DEJ and SLEB in cosmetics: skin health with clarius PAL HD Scanner by Dr Goya Análisis via ZOOM #33

27 March 2025

In the world of advanced cosmetics, technology plays a key role in the evaluation and development of innovative products. One of the most studied aspects in dermatology and aesthetics is the impact of ageing and oxidative stress on the skin. To better understand these effects, practitioners rely on high-precision diagnostic tools such as the Clarius PAL HD Scanner, capable of analysing essential structures such as the dermoepidermal junction (DEJ) and the subepidermal low echogenicity band (SLEB).

THE IMPORTANCE OF THE DEJ AND SLEB IN SKIN HEALTH

The dermoepidermal junction (DEJ) is a fundamental structure in the skin that connects the epidermis to the dermis, providing mechanical support, nutrient exchange and a barrier against external aggressions. Its integrity is essential for skin firmness and elasticity, but over time and with exposure to environmental factors, its structure weakens, leading to visible signs of ageing such as sagging and wrinkles.

On the other hand, the subepidermal low echogenicity band (SLEB) is a key indicator in dermatological ultrasound studies. This band, visible with the Clarius PAL HD Scanner, shows alterations in the skin related to ageing and oxidative stress. Thickening of the SLEB may indicate inflammation and dermal damage, while thinning of the SLEB suggests loss of collagen and elastin, leading to a reduction in the skin’s ability to regenerate.

Recent studies highlight that SLEB correlates with the presence of solar elastosis and changes in the extracellular matrix. Research has shown that dermatological ultrasound is a reliable method to assess dermal degradation and the efficacy of anti-ageing treatments.

Oxidative Stress and its Impact on the Skin

Oxidative stress is a determining factor in skin ageing. It occurs when there is an imbalance between free radicals and antioxidants in the skin, which damages cellular structures and accelerates the degradation of the extracellular matrix. This process directly affects the integrity of the DEJ and the structure of the SLEB, promoting the appearance of wrinkles, sagging and loss of radiance.

Exposure to environmental factors such as UV radiation, pollution and stress contribute significantly to this process. In response, modern cosmetic treatments seek to neutralise oxidative stress and stimulate skin regeneration through the use of antioxidants, peptides and firming actives.

Clarius PAL HD Scanner: Innovation in Skin Assessment

The Clarius PAL HD Scanner is a state-of-the-art tool that enables aesthetics and dermatology professionals to obtain high-resolution ultrasound images to accurately assess the state of the DEJ and SLEB. Its wireless technology and ease of use make it an essential device for clinical studies and cosmetic treatment optimisation.

Benefits of the Clarius PAL HD Scanner in Cosmetics

– Early Detection of Skin Damage: Identifies alterations in the SLEB and structural changes in the DEJ before they are visible to the naked eye.

– Treatment Evaluation: Allows measurement of the effectiveness of antioxidant, firming and regenerative products through objective skin analysis.

– Accurate and Comparable Data: Facilitates the monitoring of skin evolution, allowing protocols to be adjusted according to the patient’s response.

– Portable and Efficient Technology: Its wireless design and connectivity with mobile devices facilitate immediate access to high-definition images.

Applications in the Cosmetic Industry

The use of the Clarius PAL HD Scanner in the cosmetics industry has revolutionised the way new treatments are designed and tested. Thanks to its ability to assess the impact of oxidative stress and other factors on the skin, it allows laboratories to formulate more effective products based on scientific evidence.

Some notable applications include:

– Development of Anti-Aging Cosmetics: Objective measurement of skin regeneration following the use of active ingredients such as hyaluronic acid, retinol and vitamin C.

– Optimisation of Aesthetic Procedures: Pre- and post-treatment evaluation of procedures such as radiofrequency, laser and mesotherapy.

– Clinical Studies and Regulation: Validation of efficacy for the approval of new products in the market.

The combination of science and technology in the cosmetic sector allows a better understanding of skin ageing and the impact of oxidative stress on the skin. The assessment of DEJ and SLEB using the Clarius PAL HD Scanner provides valuable information for the formulation and application of more effective treatments.

This advanced diagnostic device not only improves the quality of treatments, but also boosts consumer confidence by offering products backed by scientific evidence.

In a market where innovation is key, the Clarius PAL HD Scanner is positioned as an indispensable ally to enhance efficiency and safety in modern cosmetics.