Extract of the lecture we find specifically interesting considering testing vision
Epidermal keratinocytes have been recognized to form the water impermeable structure and this barrier function is critical, especially for terrestrial animals. However, recent findings have dramatically changed the picture of epidermal keratinocytes, placing them at the forefront of the sensory system.
Among the multiple test systems applied to in vitro pharmacotoxicology the 3D reconstituted human tissues are the gold reference to quantify human skin responses because they present multiple advantages in terms of reproducibility, sensitivity and biological relevance.
The function of the epidermis is to establish a barrier between the body and its external environment. This vital function is mainly achieved by the uppermost epidermal layer, the stratum corneum, through its high mechanical strength, its ability to reduce the penetration of UV radiation and to prevent the infiltration of chemicals, allergens and microorganisms, and its capacity to limit water and electrolyte loss from the body.
This innovative study gives a new outlook on the skin barrier function by focusing on the mechanisms of mitochondrial defense. Indeed, while mitochondria are essential organelles responsible of cellular energy supply, they are also highly sensitive to various aggressions.
Cutaneous bioavailability is crucial for skin and systemic safety assessment of topically-exposed compounds. Its estimation refinement becomes a major concern since the generation and use of animal test data to support the marketing of cosmetics ingredients has been banned within the EU.
La technique SIMS pour « Secondary Ion Mass Spectrometry » est une technique d’analyse d’échantillon pouvant conduire à des images de la composition de la surface analysée. Cette technologie consiste à pulvériser les couches atomiques superficielles d’un échantillon solide en le bombardant par un faisceau d’ions Cs+, appelé faisceau d’ions primaires.
Skin permeability barrier is situated in the lower portion of the horny layer (stratum corneum, SC), at the top of the epidermis. This final product of epidermal terminal differentiation is composed of dead keratinocytes embedded in lipid extracellular matrix.
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