Perimenopause and menopause are natural stages in a woman’s life, characterized by hormonal changes that affect multiple body systems, including the skin, hair, and oral health. The decline in estrogen negatively impacts skin structure, leading to dryness, loss of elasticity, reduced dermal density, and the appearance of wrinkles. Additionally, hair changes such as thinning and hair loss are common, along with an increased risk of dental and periodontal issues. This article discusses the main physiological changes in these areas, the available cosmetic solutions, and methodologies to assess the effectiveness of these treatments.